Boobs, tatas, jugs, melons, mammary glands — you can bounce on all of them at the Museum of Sex. At the Museum of Sex, you are allowed to enter heaven for just two minutes and three dollars. Heaven, in this case, is an adults-only, X-rated bouncy house, decorated with a diverse collection of inflatable boobs. It combines reckless abandon comparable to childhood memories at the fair with the less-acknowledged sexuality and pleasure lying deep in the shadows of the fairgrounds. The Museum of Sex turns up the sexuality while still staying true to the playful nature of fairgrounds.
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1. Introduction
Photograph: Darkroom Demons. Once the first city when it came to sin and vice, Chicago's reputation for nocturnal activity has slipped in the century since. That doesn't mean it has cleaned up completely. These days, it might look wholesome on the outside, but come nightfall the freaks, wild things and deviants come out to play.
The use of animal models to investigate experimental questions about impulsive behavior can provide valuable insight into problems that affect human health. The delay-discounting paradigm involves subjects choosing between smaller reinforcers delivered immediately and larger reinforcers that are delivered after a delay. This is an important experimental paradigm for examining impulsive choice in both laboratory species and humans. However, a shortcoming of previously published delay-discounting studies in animals is that typically only males were studied, reducing the applicability of these studies to human populations. In the present study, both female and male adult Long-Evans rats were trained to perform a delay-discounting task, with delays of 0, 5, 10, 20 and 40 s before delivery of the larger reinforcer. Because dopaminergic signaling is important in mediating this task, the effects of d -amphetamine and the dopamine receptor antagonist, cis -flupenthixol, on task performance were then examined. The main experimental measure was percent larger-reinforcer choice, which was defined as the percentage of experimental trials at each delay in which the delayed, larger reinforcer was chosen. There was not a sex difference in percent larger-reinforcer choice during baseline performance of the task. In contrast, cis -flupenthixol did not have a sex-related effect on percent larger-reinforcer choice. These findings parallel the sex differences in response to amphetamine seen in human delay-discounting studies and underscore the importance of evaluating sex-based differences in baseline performance and in response to pharmacologic agents when utilizing animal models.
